Description
Chair person: Wojciech Potrzebowski
We investigate the effect of crowding on the short-time tracer diffusion of model proteins on the nanometer length and (sub-)nanosecond timescales both experimentally and with the aid of computer simulations [1]. Experimentally, we dissolve polyclonal immunoglobulin (Ig) antibody proteins of natural isotopic abundance as tracers in perdeuterated Escherichia coli cell lysate as crowder to mimic...
Finding harmless stabilizing compounds for proteins and nucleic acids is an important task in modern food and pharmaceutical industries. In this work sucrose and trehalose were investigated as stabilizing agents for myoglobin and the Aβ(1-42) peptide. Atomistic molecular dynamics (MD) simulations were carried out for several systems of myoglobin/Aβ(1-42) in both water and aqueous solutions of...
Structure and Dynamics of Huntingtin. A Segmental Labelling Approach
Xamuel L. Lund [1], Amin Sagar [1], Frank Gabel [2], Anne Martel [3], Pau Bernadó [1]
[1] Centre de Biochimie Structurale (CBS), INSERM, CNRS, Université de Montpellier, 34090 Montpellier, France
[2] Université de Grenoble Alpes, CEA, CNRS, IBS, 38044 Grenoble, France
[3] Institut Laue-Langevin (ILL), 38044 Grenoble,...
Pentameric ligand-gated ion channels transform chemical signals into electrical ones, a process during which they undergo subtle conformational cycling resulting in rapid, reversible gating of an intrinsic transmembrane pore. The pH-gated bacterial channel GLIC has proved a valuable model system for this receptor family, in part due to its accessibility to X-ray crystallography - which has...
