Speaker
Anna Leung
(European Spallation Source ERIC)
Description
The Chemical Deuteration Laboratory (DEULAB) at the European Spallation Source ERIC (ESS) has been established in anticipation of the increasing demand for deuterated molecules as a result of the construction of the powerful new neutron source. As part of the Deuteration and Macromolecular Xtallization (DEMAX) platform of ESS, it complements the planned ESS activities for the production of deuterium-labelled macromolecules for neutron scattering.
The newly-established DEULAB will augment the current capabilities of laboratories at ISIS, ILL and FZJ, the expertise of which is leveraged through joint efforts towards deuteration via the Deuteration Network DEUNET. In addition to the Deuteration Network members, DEULAB utilizes partnerships with local institutions such as the Lund Protein Production Platform (LP3) at Lund University.
Deuteration at DEULAB will focus on the chemical synthesis of complex deuterated molecules, and on the development of novel deuteration methods. Current work centres around the use of cell-free, enzymatic transformations of deuterated precursors to produce synthetically challenging molecules, and the derivatisation of deuterated cell culture components to access complex deuterated molecules through combined biological-chemical deuteration. Both of these projects are collaborations with other members of DEUNET, allowing the production of materials otherwise not available. Following an update on the current DEULAB status, an overview of the current research projects and results will be presented.
Primary author
Anna Leung
(European Spallation Source ERIC)
Co-author
Hanna Wacklin
(European Spallation Source ERIC)
