15–17 May 2017
Oxford Spires Hotel
Europe/Stockholm timezone

Understanding the nanoparticle-protein complexes and their biological effects using neutrons

Not scheduled
20m
Oxford Spires Hotel

Oxford Spires Hotel

Abingdon Rd Oxford OX1 4PS UK
Invited Speaker Soft Matter and Colloids – applications

Description

Francesca Baldelli Bombelli Laboratory of Supramolecular and BioNano Materials (SupraBioNanoLab), Department of Chemistry, Material and Chemical Engineering G.Natta, Politecnico di Milano, Milano, Italy The fast development of nanotechnology and growing use of nanomaterials in different fields increased the chance to voluntary or accidental exposure of the human body to nanoparticles (NPs), which could in some cases lead to adverse effects for health. Thus, a clear understanding of the interaction of NPs with the biological matter is crucial and not only limited to nanomaterials specifically developed for biomedical applications. Most of the difficulties encountered by the nanoformulations to reach the clinics are not only due to issues related to the scaling-up of the production methodologies, but also to the complexity of the interaction between NPs and biological matter. The first contact between NPs and living organisms occurs in the biological fluid, where protein-NP complexes are immediately formed, then these protein corona (PC) NPs will first interact with the cell membrane. Thus, understanding PC NP–cell interactions is a critical step to design safer and more efficient NPs as well as to predict possible toxicity effects. In this work the use of neutrons to study the formation of PC NPs and their effect on lipid membranes will be shown: in particular how neutron-based techniques can represent optimal complementary methodologies to better understand the interaction of nanomaterials and biological matter.

Primary author

Prof. Francesca Baldelli Bombelli (Politecnico di Milano)

Presentation materials

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