Speaker
Dr
Malin Zackrisson Oskolkova
(Assoc. Prof., Division of Physical Chemistry, Lund University)
Description
We present a robust framework for pinpointing patchy intermolecular interactions from scattering data. Our analysis is based on a SAXS/SLS study of the milk protein lactoferrin which forms highly stereo-specific dimers, resulting in a non-monotonic dependence of the second virial coefficient on electrolyte concentration.
The results are interpreted using an integral equation theory that accounts for isotropic, electrostatic repulsion and a directional patch that allows for dimers, but precludes trimer formation. This model captures the complete transition pathway from monomers in the dilute limit, to monomer-dimer systems at somewhat higher protein concentrations.
Primary author
Dr
Malin Zackrisson Oskolkova
(Assoc. Prof., Division of Physical Chemistry, Lund University)
Co-authors
Dr
Björn A. Persson
(Division of Theoretical Chemistry)
Prof.
Johan Bergenoltz
(Department of Chemistry and Molecular Biology, Göteborg University)
Dr
Mikael Lund
(Division of Theoretical Chemistry, Lund University)
Mr
Weimin Li
(Division of Physical Chemistry, Lund University)
